13 Jan, 2021

Senior Scientist Group Lead Process Development

  • Merck
  • St. Louis, MO, USA
Process Engineer   Biochemicals / Pharmaceuticals

Job Description

Your Role:


The ideal candidate will lead a team of 4 people to accomplish bio-conjugation process chemistry technology transfer and development campaigns designed to deliver robust and cost-effective production processes to GMP manufacturing.

  • Leverage experience in protein biochemistry and/or conjugation chemistry to on-board/develop, optimize, and scale-up bio-conjugation process chemistry unit operations
  • Effectively work with key stakeholders to technology transfer time-sensitive bio-conjugation production processes to GMP manufacturing
  • Troubleshoot bio-conjugate production process non-conformances and deliver data-driven solutions
  • Responsible for day-to-day management of direct reports and projects
  • Exempt role and extended days and/or possible weekend shifts for special projects occur occasionally throughout the year


Physical Attributes:

  • Perform moderately physical activity.
  • While performing the duties of this job, the employee may work near moving mechanical parts; fumes or airborne particles; toxic or hazardous chemicals.  The noise level in the work environment is usually moderate.
  • The employee may frequently sit, stand; walk; use hands, handle, or feel; reach with hands and arms; climb or balance; stoop, kneel, crouch, or crawl and taste or smell.
  • The employee will occasionally lift and/or move up to 50 pounds.
  • Specific vision requirements of this job include close vision, distance vision, color vision, peripheral vision, depth vision and the ability to adjust focus.
  • The employee may be required to wear an air helmet, mask, safety shoes, apron rubber and Tyvek suits, protective gloves, safety glasses and/or goggles while performing in this position.
  • The employee may be exposed to unknown biological agents


Who You Are:


Minimum Qualifications:

  • Ph.D. in Biochemistry, Chemistry, Biology, Chemical Engineering or other life science discipline with 3+ years of industrial experience OR Master’s Degree in Biochemistry, Chemistry, Biology, Chemical Engineering or other life science discipline with 5+ years of industrial experience OR Bachelor’s degree with 10+ years of industrial experience
  • 2+ years of experience in protein or other biopolymer purification at both the bench and production scale employing state of the art chromatographic and ultrafiltration unit operations
  • 2+ years of experience in working with or leading multi-disciplinary/matrix teams


Preferred Qualifications:

  • Experience in bio-conjugation process chemistry development and optimization, including the use of Design of Experiments
  • Experience with oligo nucleotide purification on a preparative scale
  • Experience related to chemical and/or enzymatic conjugation of small molecule payloads to biopolymer scaffolds strongly preferred
  • 2+ years of experience in managing/supervising direct reports
  • Attention to detail in planning, execution, and documentation of experimental work
  • Exemplary communication skills including timely and concise written and oral communications to both external and internal project stakeholders



Job Requisition ID:  213334
Location:  St. Louis
Career Level:  D - Professional (4-9 years)
Working time model:  full-time

Careers during Covid-19
Thank you for visiting our careers website, we are always looking for curious minds to join our teams. We understand how much the world is being impacted by the Covid-19 crisis and we want to assure you that your safety is very important to us. To ensure that everyone’s health is protected, instead of a standard face-to-face interview, it is likely that you will be offered alternative digital interview options.

US Disclosure
The Company is an Equal Employment Opportunity employer. No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, transgender status, marital status, or any other classification protected by applicable federal, state, or local law.  This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment. Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to their Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because they made a good faith report of discrimination.

North America Disclosure
The Company is committed to accessibility in its workplaces, including during the job application process. Applicants who may require accommodation during the application process should speak with our HR Services team at 855 444 5678 from 8:00am to 5:30pm ET Monday through Friday.

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