15 Dec, 2020

Senior Scientist, Process Development & Engineering

  • Merck
  • Kenilworth, NJ, USA
Process Engineer   Biochemicals / Pharmaceuticals

Job Description

Job Description

 

As a senior scientist in our company's Biologics Process Research & Development (BPRD), you will work with a highly collaborative team of scientists and engineers to design and develop upstream microbial and cell culture process to innovate and support our Company's biologic pipelines and production platforms. This position will have the opportunity to apply and integrate innovation into biologic process sciences to establish our Company as the industry leader in next-generation biologics manufacturing. In addition, we work closely with colleagues in Discovery, Pre-clinical, and Early Development to rapidly develop manufacturing processes for diverse biotherapeutics, and efficiently manufacture material to supply clinical trials. We are also responsible for late stage/commercial process development and the development of new manufacturing technologies. We work with our partners in our company's Manufacturing Division to commercialize and launch new products.    

 

Primary Responsibilities:

  • Independently design and conduct microbial and cell culture studies and analyses using a variety of analytical instruments/techniques and biological assays

  • Systematically and scientifically characterize different microbial cultures and/or mammalian cell cultures to improve process understanding and development. Champion this knowledge into biologics process innovation

  • Responsible for process automation and control to streamline cell culture lab operation  

  • Proactively partner with interdisciplinary our Company's and external scientists for study design, execution, and data analysis. Collaborate cross-functionally to deliver and advance project timelines

  • Bioprocess scale-up and technology transfer to manufacturing facilities

  • Promote, create, and implement innovative ideas for microbial and cell culture process

  • Data analysis, data interpretation, manuscript preparation, publication, and presentation

  • Contribute to a safe and compliant laboratory work environment

 

Educational Qualifications:  

  • B.S. in Chemical Engineering, Biochemical Engineering, Biomedical Engineering, Biotechnology, Biochemistry, Microbiology, or related biological fields with 7 years of relevant experience or Master's degree with 4 years or Ph.D. with some relevant academic or industrial experience 

 

Required Experience and Skills: 

  • Cell culture aseptic technique, assays and general laboratory practices

  • Microbial or mammalian cell culture process development or hands-on experience with recombinant protein expression or chemical/metabolites production using different expression systems

  • Basic knowledge of statistical methods and computer programming/analysis packages like SIMCA, JMP, R, Python or Matlab

  • Excellent stakeholder management and interactive skills; ability to work in a matrixed team environment and collaborate with both internal and external partners including vendors

 

Preferred Experience and Skills:

  • Strong scientific knowledge in microbial fermentation or mammalian cell culture process development for recombinant protein or chemical/ metabolite production

  • Background in applying cell and/or process engineering approaches for scientific investigation, problem-solving or process improvement 

  • Expertise in bioanalytical techniques such as flow cytometry, microscopy, biochemical assays, and cell functional assays to characterize microbial or cell culture processes

  • Strong knowledge of cellular metabolism and working knowledge of medium development

  • Proven records of scientific publication and communication with excellent oral and written skills

  • Demonstrated ability to think critically with excellent problem solving and troubleshooting skills

  • Basic understanding of process automation programing and bioreactor operation including ambr15, ambr250, and 3L bioreactors is highly preferred   

 

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. 

 

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

 

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

 

INVENT.

IMPACT.

INSPIRE.

 

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

 

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.


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