07 Jul, 2020

Investigator, Chemical Development

£50,000 - £85,000 yearly
  • GSK
  • Collegeville, Pennsylvania, USA
Chemical Engineer,   Process Engineer   Biochemicals / Pharmaceuticals Chemicals

Job Description

GlaxoSmithKline is recognized internationally for its innovative approach to drug discovery and development.  Our success is built on the collaboration of multi-disciplinary teams of scientists sharing their ideas and expertise. GSK’s Chemical Development group supports the small molecule portfolio in GSK Pharma R&D with an inter-disciplinary team of chemists, chemical engineers, and materials science experts by developing the synthetic routes and associated manufacturing processes that turn those molecules into medicines. Through our network of 86 manufacturing sites, each year we produce nearly 4 billion packs of medicine and we are committed to widening access to our products so that more people may benefit. 

 We are seeking a proactive chemist to join Chemical Development at our US R&D Hub located in Upper Providence, PA,  in the Philadelphia suburbs.  Just 35 miles from Philadelphia International Airport, the Upper Providence site is home to over 3,000 of our R&D staff.  With the concentration of such a large number of scientists you will find a culture that inspires innovation and collaboration, emphasizes professional development, and maintains a strong focus on the patients that are at the end of everything we do. The location also benefits from excellent facilities on site and in the surrounding area as well as shuttle services that make the campus accessible via public transportation. 

 A successful applicant will have an excellent practical and theoretical understanding of synthetic organic chemistry and can design and execute high quality, thoughtful experimentation, while making significant contributions both independently and as a member of a team. 

 Key Responsibilities include, but are not limited to:

  • Designing and performing experiments in a laboratory setting to meet project timelines and objectives.
  • Thinking creatively to generate new ideas for new synthetic routes and simplifying process problems.
  • Ensuring that experimental work is communicated effectively at internal R&D meetings.
  • Participating in technology transfer activities as appropriate to our manufacturing partners Pharma Supply Chain (PSC), other parts of R&D, and partner Contract Manufacturing Organisations (CMOs).
  • Authoring or contributing to regulatory submissions, patents, scientific papers and other internal documentation relevant to the role.
  • Complying with applicable Data Integrity, Quality, cGMP and regulatory requirements in all aspects of work.

 Why You?

As a member of Chemical Development, you will use your chemistry knowledge and expertise to develop new chemistry routes for primary manufacture and contribute to the development and deployment of state-of-the-art processes and technologies to enable the delivery of our medicines.  This is a highly practical role where you will be working in the R&D laboratories to generate new synthetic routes and process understanding that underpins the successful scale-up and commercial industrialization of GSK’s future manufacturing processes. Your focus will be to combine the information generated in laboratory studies with your strong knowledge of synthetic organic chemistry to develop sustainable pharmaceutical manufacturing routes and processes. 

As projects advance through development, pilot plant support may also be required across scales, culminating in the transfer of projects to our commercial manufacturing facilities around the globe. The role is highly technical and dynamic as you will be working in a number of multi-disciplinary project teams. You will thrive in this environment if you are able to effectively manage multiple priorities, communicate your recommendations clearly, and enjoy working in teams. 

Subject to approval of reasonable request, GSK are a modern employer and offer flexible working hours and conditions.

About You

Success in this role will require strong interpersonal skils, practical synthetic chemistry skills combined with a curious, inquisitive nature and a passion for working in the laboratory. To enjoy and excel in this position you will need to be genuinely passionate about developing yourself, developing new scientific methodology and learning new things. You will be an excellent team player, able to work with others in the lab as well as within cross-functional teams. You will be highly independent and able to plan and execute your own workload and deliver results without constant supervision.  Your experimental results will be of the highest quality.  You will be able to clearly, concisely, and effectively communicate your scientific results to audiences of varying scientific background.  You will be required to work in a laboratory with an emphasis on safety.  Previous experience in mulstistep synthesis of complex organic molecules and your creativity in solving organic chemistry problems will be an asset to you in this role.

 Basic Qualifications

We are looking for professionals with these required skills to achieve our goals:

  • Ph.D. in Chemistry or equivalent industrial experience
  • Expertise in state-of-the art synthetic organic chemistry
  • Scientific record demonstrating excellence in chemistry (e.g. publications, patents, or presentations)
  • Experience in independent planning and execution of experiments
  • Experience in independent interpretation of data from experiments and using it to make meaningful conclusions/decisions regarding the direction of future experimentation

 Preferred Qualifications

If you have the following characteristics, it would be a plus:

  • Experience in multistep synthesis of complex organic molecules
  • Experience with high throughput experimentation for reaction optimization and process development activities is a plus, but not required.
  • Experience with Design of Experiments (DoE) is a plus, but not a requirement.
  • Experience in implementation of basic kinetic characterization of organic reactions is a plus, but not required.
  • Excellent problem-solving skills
  • Has the courage to take on ambitious goals and move forward at pace
  • Takes accountability by holding self and others to the commitments that have been made
  • Ability to learn and grow through challenging work and is willing to give and receive constructive feedback as part of an effort to continuously improve

When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

  • Operating at pace and agile decision-making – using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness

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GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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